Breast Cancer Grand Round with Dr Michelle Li
Antibody-drug conjugates (ADCs) in cancer treatment
June 11 2025
Antibody-drug conjugates (ADCs) have rapidly emerged as a highly effective strategy in the treatment of cancers of different histologies, including metastatic breast cancer. The use of engineered monoclonal antibodies that target a tumour-associated antigen and are linked to a cytotoxic payload offers the opportunity for more precise delivery of chemotherapy.
With the use of trastuzumab deruxtecan, sacituzumab govitecan and other ADCs becoming increasingly more common in our clinical practice, several gaps in our knowledge are raised – including the mechanisms behind development of cross-resistance, and the most optimal sequencing of treatments to provide maximal benefit to our patients.
Warning: The VCCC Alliance Breast Cancer Grand Round is targeted at a clinical audience and features open discussion about real cases and patients. While these cases are de-identified, the imagery, content and discussion can be graphic. It is not appropriate for consumer participants.
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Speaker
Prof John Crown BCh BAO BSc MBA FRCPI
Consultant Medical Oncologist,St Vincent’s Medical Group in Dublin, Ireland; Professor of Medicine, University College Dublin; Thomas Baldwin Chair in Translational Cancer Research, Dublin City University.
Prof Crown graduated Medicine and Science from University College Dublin, trained in general medicine in London and Dublin, and in Oncology at Mount Sinai Medical Centre New York and Sloan Kettering Memorial Cancer Centre. He subsequently served at the faculty at Memorial Sloan Kettering Cancer Centre and Cornell Medical School where he was an Assistant Professor.
He is the founder of The Irish Clinical Oncology Research group and has authored and co-authored over 300 manuscripts in the field of cancer research. He is also a member of The Royal Irish Academy and served in Seanad Eireann and representing The National University of Ireland constituency from 2011 to 2016.
During his time in The Seanad, he served under the Oireachtas Health Committee and The British Irish Parliamentary Association and was the author of legislation which resulted in a ban on smoking in cars, where children are present.
Resource details
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