Dr Chen's main research interests are gene expression, alternative splicing, single-cell and spatial-omics analysis, as well as the application of these cutting-edge technologies in cancer research. His laboratory has extensive experience and strong expertise in differential gene/transcript expression and pathways analysis in bulk and single-cell RNA-seq experiments. Over the last decade, Dr Chen and his group has been working closely with cancer researchers, especially the Breast Cancer Lab at WEHI, focusing on cancer genesis and the identification of cancer cell-of-origin.