A/Prof Goel leads a research group that positions itself at the intersection of cell cycle biology, epigenetics, and tumour immunology. He has made seminal insights into the mechanisms underlying the activity of and resistance to cell cycle inhibitory drugs.

Most recently, his team has focused on understanding therapy-induced senescence in cancer and he has been awarded a Snow Medical Fellowship and US DOD Era of Hope Scholar to support this work. A/Prof Goel serves as PI randomised clinical trials in breast cancer, all of which stem directly from his laboratory discoveries. He also served as Chair of the American Society of Clinical Oncology Education Committee in 2022-3.