RECAP Journal Club: DYNAMIC trial with Professor Jeanne Tie
Five-year outcomes of the randomised DYNAMIC trial
Tune in with Professor Jeanne Tie, as she discusses the landmark DYNAMIC trial, five years on. This pivotal study investigates how circulating tumour DNA (ctDNA) analysis can guide adjuvant chemotherapy decisions for patients with stage II colon cancer.
With five-year outcomes now available, the trial demonstrates that a ctDNA-guided approach can safely reduce chemotherapy use without compromising survival, while also providing new insights into ctDNA clearance, tumour burden, and long-term recurrence risk.
In this session, Professor Tie, joined by our hosts Dr. Sam Harris and A/Professor Craig Underhill, unpack the trial's design, methods and key results, as well as discuss the paper's strengths and limitations, and what the findings mean for regional and rural clinicians and their patients.
Author in the Room Series
The RECAP (Regional Evidence, Collaboration and Practice) Journal Club is a quarterly initiative supported by the Cancer Patient Support Program (CPSP) Grant, showcasing peer-reviewed articles that reflect international best practice, led by regional hosts and paper authors.
Author in the Room
Professor Jeanne Tie
VCCC Alliance Research and Education Lead, Lower Gastrointestinal Cancer
Medical Oncologist, Peter MacCallum Cancer Centre; Senior Research Fellow, WEHI
Professor Tie is a clinician researcher and consultant medical oncologist specialising in the management of lower gastrointestinal cancers (colon, rectal and anal cancer). She is the Medical Oncology Lead for the Lower GI tumour stream at Peter Mac and a senior research fellow within the division of personalised oncology at the Walter and Eliza Hall Institute. Following a clinical trial fellowship at the Royal Melbourne Hospital, her post-graduate research degree focused on the genomic biomarkers in colorectal cancer.
Hosts
Dr. Samuel Harris
Medical Oncologist, Bendigo Regional Cancer Centre, Bendigo Health
Dr Harris graduated from Adelaide University Medical School and has extensive postgraduate general medical, oncological and palliative care experience. In 2013, he completed medical oncology advanced training at Bendigo Health, Peter MacCallum Cancer Centre and the Austin Repatriation Hospital. His final year was a clinical trials fellowship in breast cancer, gastro-intestinal tumours and genitourinary cancers.
Between 2014 and 2016, Dr Harris undertook a fellowship at the Royal Marsden Hospital in London, United Kingdom, working initially in the Sarcoma Unit and subsequently with Professor Johann De Bono in the Drug Development Unit (phase 1 trials) and the prostate team.
Dr Harris is a medical oncologist at the Bendigo Health Cancer Centre and also has a fortnightly visiting clinic to Kyneton Regional Health. He is the Clinical Lead for the Oncology Trials Unit. His specialty areas are in breast cancer, melanoma, lung cancer and general oncology.
A/Professor Craig Underhill
Medical Oncologist and Health Services Researcher, Albury Wodonga
Prof Underhill is a medical oncologist and researcher based in Albury Wodonga. He is Conjoint Associate Professor, University of NSW Rural Clinical School Albury, Adjunct Professor at The John Richards Centre for Rural Ageing Research, Latrobe University and an Honorary Research Fellow at Peter MacCallum Cancer Institute. His research interests include addressing inequity of access to cancer care for regional Australians including First Nations peoples and the use of telehealth to improve access to clinical trials.
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