Davis started in Bioinformatics as a UROP student (and Honours student, and RA) with Prof Gordon Smyth in the Bioinformatics Division at the Walter and Eliza Hall Institute in Melbourne, Australia. He worked on differential expression methods for RNA-seq data, most notably the edgeR package. He completed a DPhil in Statistics at the University of Oxford under the supervision of Prof Peter Donnelly, supported by a General Sir John Monash Scholarship. Davis then undertook a postdoc in Dr Oliver Stegle's group at the European Bioinformatics Insitute in Cambridge, UK. At EBI, Davis worked on single-cell methods development and on projects linking DNA variation to single-cell gene expression. He returned to Melbourne in late 2018 to start the Bioinformatics and Cellular Genomics group at St Vincent's Institute of Medical Research, is an honorary Principal Research Fellow in the Faculty of Medicine, Dentistry and Health Sciences at the University of Melbourne, and is an Associate Member of Melbourne Integrative Genomics. Davis's lab works on methods development and collaborative projects with a focus on single-cell and spatial 'omics and medical imaging.