Monday Lunch Live x Breast Cancer Grand Round
23 February 2026 (Video recording below)
Translating tumour biology to the clinic: Tackling heterogeneity and resistance in breast cancer
International expert Professor Aleix Prat discusses how gene expression profiling (GEP) can translate tumor biology into clinically actionable decisions across breast cancer subtypes.
Prof Prat illustrates how on-treatment GEP in HR+/HER2− breast cancer provides dynamic biological insight, supports the concept of molecular downstaging, and may enable chemotherapy avoidance in selected patients. In HER2-positive disease, he addresses the marked biological heterogeneity of tumors and present evidence supporting HER2DX as a genomic tool that integrates tumor and immune biology to predict treatment response and stratify risk, informing treatment intensity.
Finally, Prof Prat explores tumor evolution and mechanisms of resistance in metastatic HR+/HER2− breast cancer, highlighting intrinsic subtype shifts and FGFR4 upregulation as drivers of endocrine resistance and as emerging therapeutic targets.
Chair
Dr Stephen Luen
Medical Oncologist and Translational Researcher, Peter MacCallum Cancer Centre
Dr Luen is an early career medical oncologist and translational researcher specialising in breast cancer, sarcoma, early drug development, and precision oncology. In 2021, he completed a PhD supervised by Professor Sherene Loi investigating genomic and immune biomarkers in early-stage breast cancers, and continues to work closely with the laboratory. His current research interests include the development of novel clinical trial approaches for high-risk breast cancers, the early phase development of new therapeutic compounds, and the study of genomic and immune biomarkers in high-risk and treatment-refractory breast cancers.
Speakers
Professor Aleix Prat MD PhD
Medical oncologist, researcher, educator, and entrepreneur;
Professor of Medicine, University of Barcelona
Prof Aleix Prat is internationally recognised for his contributions to precision oncology, particularly in breast cancer. He trained in medical oncology at Hospital Vall d’Hebron under Dr. Josep Baselga (2004–2008) and pursued his research education in the United States in the laboratory of Dr. Charles M. Perou at the University of North Carolina at Chapel Hill (2008–2012). He led the Medical Oncology Department at Hospital Clínic de Barcelona from 2014 to 2022, before taking on broader leadership roles as Director of the Institute of Cancer and Blood Diseases (2023) and the Clinic Barcelona Comprehensive Cancer Center (2024).
Prof Prat is a tenured professor of medicine at the University of Barcelona. At the cancer center, he directs a translational genomics laboratory that developed HER2DX, the first genomic assay for HER2-positive breast cancer, now implemented in Europe and the United States, and is advancing novel assays such as TNBCDX and DNADX. As an entrepreneur, he co-founded Reveal Genomics in 2020 and serves as Chief Clinical Advisor at Ona Therapeutics, contributing to the development of innovative precision oncology tools and therapies.
Resource details
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