Turning cancer’s off‑switch back on

Published Catarina de Freitas on

Monday Lunch Live

27 April 2026 (Video recording below) 

Turning cancer's off-switch back on: First proof-of-concept for selective reactivation of a tumor suppressor

Dr Alison Schram from Memorial Sloan Kettering Cancer Center, USA presents data from the PYNNACLE trial, a study of rezatapopt in TP53 Y220C-mutated cancers. This trial is the first proof-of-concept for selective reactivation of a tumor suppressor for the treatment of cancer.  
 

Chair 

Dr Julia Dixon-Douglas
Medical Oncologist
Peter MacCallum Cancer Centre

A recipient of the Breast Cancer Trials International Fellowship grant in 2023, Dr Julia Dixon-Douglas recently returned from Institut Gustave Roussy in Paris, France, where she spent two and a half years working in translational research as part of her PhD, as well as working with the multidisciplinary breast service at Gustave Roussy and contributing to their liquid biopsy precision medicine program.

Speaker

Dr Alison Schram MD
Associate Attending Physician Section Head, Oral Therapeutics Early Drug Development and Gynecologic Medical Oncology Services, Memorial Sloan Kettering Cancer Center

Dr Schram is a medical oncologist and clinical investigator at the Memorial Sloan Kettering Cancer Center in New York, USA. Her work focuses on early-phase clinical trials and the development of new, targeted cancer therapies.

Dr Schram’s research aims to identify and target the molecular changes that drive tumours, helping to tailor treatments to individual patients through precision oncology approaches. She leads and contributes to early drug development studies designed to bring promising therapies from the laboratory into clinical trials for patients with advanced cancers.

She earned her MD from the University of Pennsylvania School of Medicine and completed her internal medicine residency at Brigham and Women’s Hospital, followed by a fellowship in medical oncology at Memorial Sloan Kettering. In addition to her clinical and research roles, Dr Schram has received recognition for her contributions to clinical research, including awards supporting innovative cancer investigation and leadership in clinical trials.

Resource details

Dr Alison Schram
Course type
Webinars
Duration
60 mins
Price
$0.00
Curriculum Area
Research (incl. Clinical Trials)
Speciality
Clinician
Early to mid career researcher
Senior researcher / scientist
Clinical trials
Drug discovery
Monday Lunch Live
Research

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